Cardioprotective effects of ischemic preconditioning can be recaptured after they are lost
نویسندگان
چکیده
منابع مشابه
Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning.
Ischemic postconditioning (PostC) and perconditioning (PerC) provide practical methods for protecting the heart against ischemia-reperfusion (I/R) injury, but their combined effects have not been studied in detail. Using an in vivo rat I/R model, we tested 1) whether additive effects were produced when local PostC was preceded by varying doses of remote PerC, and whether the optimal PostC+PerC ...
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Background and objectives: Potentilla reptans L. from Rosaceae family is used as traditional medicine in Iran and other countries. Previous investigations on Potentilla species have reported strong antioxidant activity and cardioprotective effect. In this study, antioxidant activity of aerial parts and root of Potentilla reptans, and...
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A growing body of animal studies provides evidence for potential cardioprotective effects of inhibitors of the enzyme phosphodiesterase isoform 5. Infarct size reduction by administration of phosphodiesterase 5 inhibitors was described in various experimental models of ischaemia and reperfusion. Furthermore, potential beneficial effects were demonstrated in experimental models of congestive hea...
متن کاملIschemic preconditioning is not cardioprotective in senescent human myocardium.
BACKGROUND Cellular and functional changes secondary to aging could impair myocardial tolerance to ischemia and affect the heart's response to ischemic preconditioning. METHODS We investigated the impact of cardiac aging on preconditioning in right atrial trabeculae of adult patients (< or = 55 years) and senescent patients (> or = 70 years) with coronary artery disease. Specimens were subjec...
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We examined the role of cyclooxygenase-2 (COX-2) in the late phase of ischemic preconditioning (PC). A total of 176 conscious rabbits were used. Ischemic PC (six cycles of 4-min coronary occlusions/4-min reperfusions) resulted in a rapid increase in myocardial COX-2 mRNA levels (+231 +/- 64% at 1 h; RNase protection assay) followed 24 h later by an increase in COX-2 protein expression (+216 +/-...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1994
ISSN: 0735-1097
DOI: 10.1016/0735-1097(94)90435-9